Cellular signaling networks are involved in regulating control of almost all aspects of cell biology in normal and pathophysiological contexts.  Research in the White lab is focused on defining the dynamic cellular signaling response to perturbation in healthy and diseased cells, tumors, and tissues.  In this effort, we combine cutting edge analytical methods with data-driven computational modeling to integrate across molecular and phenotypic data sets and define the signaling nodes that are most relevant for a given phenotype.  At the translational level, much of the research in the lab is aimed at defining the adaptive response to current therapies that underlie therapeutic resistance and limit therapeutic efficacy.